join us at astra.place to vote on which eu leaders are sustainable
scandals 20 years in making - how govs underinvested in basic mnra research ...also 20 years ago i was lucky to meet a professor of nature at bath uni -i am terrified by what he knows but top down medical bureaucrats dont

1 twitter smart virus lists v0 v2 ==

rsvp chris.macrae@yahoo.co.uk sources by and for all -why experts in ebola are not in covid

close encounters:
of healthy kind, of servant leader kind, of food security, of education kind, of credit kind, of solar kind, of other machine intel kind
37th year of economist debate- who will get last mile in time forpost-covid's sdg generation?- biden?, africa?, bangladesh?, far east islands, rest asia continent, euro, latinam, womens lives, colored lives...my second most exciting moment in life- meeting sir fazle abed 1 2- he had designed a rural health service for one of the ten most populous nations from scratch? which do you think sir fazle need more help from health genii or financial genii? -more here

2020 telehealth hinge moment
our biggest challenge in 2020s is not the virus it is failing to unite around designing a world so next girl or boy born has a joyful chance at a productive life- that depends on 3 skills thriving in ever community - the health servant (economisthealth.com), the livelihood educator (economistuniversity.com) and the financial servant (economistbank.com.)
however we have known since the end of world war 2 that we need new maps than those that 8 largest empires had ruled planet with - and that 4 new technologies and types of mediation will multiply this sustainably up or crashing down until mother natures selects us as next dod- more at girlsworldbank.com
who published 13 global health challenges 1/13/2020 - help update them -related search malaria : fda -messy https://www.the-scientist.com/news-opinion/nih-cancels-funding-for-bat-coronavirus-research-project-67486

virus unknowns help unwomens list some twitter dialogues 1 2 3 chris.macrae@yahoo.co.uk
ByeBye human race unless you can help us find medical word's top 10 World Record Jobs Creators 9 8 7 ...Ironically knowledge of the curriculum of entrepreneurial revolution - as the net generation's opportunity to collaborate in human sustainability peaked in 1984 - unless you can help World Record Jobs Creators retrieve it now - thanks chris macrae wash dc text 240 316 8157 EconomistDiary.com ERworld.tv amychina.net Anyone seriously transparent about affordable global health and sustainability needs to develop segments of health services and then decide whether an integrated service is still to have place boundaries. THE BLOCKCHAIN WARS. New media is always a battle between the forces for evil who linkin fast and those who needed to open space for a deeper social order (which takes time). Understanding blockchain mapping will also be absolutely essential: it may be how sustainability's last call is won by little sisters or lost to big brothers. these are the most exciting times to be alive.. 4 markets human sustainability depends on health & . linkedin UNwomens - question collab blog editors: chris.macrae@yahoo.co.uk washington DC

china; Qatar bangladesh and asean ghana france india

usa CHINA UNICORNS

good news china's robot teachers assistants will soon be better at diagnosis than 99% of docs. china
............



online library of norman macrae...world record jobs creators: sir fazle abed .. jim kim.JKU. larry brilliant.. gerge soros..paul farmer .leana wen .BillionGirlsBoys network
health.nutrition.edu.green.job


Tuesday, December 31, 2013

Bloomberg
thanks bloomberg newsletter week 2 of bidenomics -42 weeks to glasgow cop26

To the untrained ear, “protein space” sounds like a cheeky name for a bodybuilding gym. For the evolutionary biologist, however, it’s a place to spend a career. Coined by the pioneering theoretical biologist John Maynard Smith in 1970, the term is a metaphor for the computational landscape where scientists can survey every possible sequence of a particular protein, trace its historic path of evolution, and even predict where natural selection might locate its next biophysically viable mutation — in other words, how the protein will adapt and express itself in real life. 

Representations and applications of John Maynard Smith’s “Protein Space.” “A” shows the simplest path through a computational space to solve a word puzzle, where only one letter can be changed at a time to get from “word” to “gene.” “B” shows the same concept, but applies it to mutations in a real protein sequence. 

Graphic: Genetics, April 2020

Right now, this protein “mapping” is playing a crucial role in the quest to understand SARS-CoV-2, the virus that causes Covid-19. Researchers around the planet are studying the protein spaces of the deadly virus so that vaccines and therapies can effectively fight it.

Among them is Tyler Starr, a postdoctoral researcher at the Fred Hutchinson Cancer Research Center. In a paper published in June, Starr and his colleagues did a mapping experiment to determine how mutations in the “key” part of the virus (aka the “receptor binding domain”) could affect its ability to lock into the “keyhole” (aka ACE2 receptors) of human cells. They located sequences that significantly improved that binding, but those sequences hadn't been detected in nature yet. 

But now they're infecting humans. One of those mutations to the RBD, known as N501Y, has come to scientists’ attention due to its repeated emergence in several global lineages such as the "B.1.1.7" lineage first identified in the UK. "Now it’s only rising in frequency,” said Starr. He and other scientists aren’t sure if that’s due to adaptive pressures on the virus created by immunity, or due to other changes in its structure. But these are questions that protein mapping can help with: Scientists can think about mutating proteins traversing a “fitness landscape” that is shaped by shifting evolutionary pressures. They can build models to try and see where it’s going next, and to try to fend it off before it gets there.

That’s another thing Starr is working on: His latest paper maps possible future mutations in a part of the virus’s protein structure that could make it less receptive to antibody treatments. That way, future antibody therapies could be strengthened against those potential mutations, helping humanity finally map its way out of Covid-19. 

Starr's latest research includes what he calls "maps" of mutations that escape binding by antibody treatments, where the X axes show different protein sequences and Y axes show how those sequences impact binding. The color scale refers to effects on ACE2 binding.

Graphic: Science, January 2021

Frontline workers: Let us map with you

Walee Phiriyaphongsak/Bloomberg CityLab

Walee Phiriyaphongsak/Bloomberg CityLab

As part of our ongoing Covid-19 mapping project, CityLab wants to document and include the experiences of people who work in healthcare, food service, transportation, education, manufacturing, processing or any other frontline field. If you’re interested in sharing your pandemic experience and working with an artist to turn it into a map, please send an email to maplab@bloomberg.net with your location, occupation and some ideas about what you’d like to visualize. A CityLab journalist will be in touch.

Map links

  • Amnesty International is building a crowdsourced map of surveillance cameras in global cities (Fast Company)
  • How different countries have helped those who've lost income during the pandemic (Visual Capitalist)
  • In the U.S., electoral redistricting is shaping up to be a major political war (Axios)
  • Why snow maps deserve your scrutiny (Washington Post)

Stay healthy, stay safe. Sign up for MapLab here.

Laura Bliss

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